Trimethacarb is an insecticide and animal repellent. It is moderately soluble in water, is quite volatile and there is also a slight risk of leaching to groundwater. It is not generally persistent in soil systems. It may degrade quickly via hydrolysis in aquatic systems. It is moderately toxic to mammals but would not be expected to bioaccumulate. It is an acetyl cholinesterase inhibitor and a neurotoxin. It shows a moderate to high level of toxicity to most aquatic species.
Data alerts
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Environmental fate Moderate alert: Moderately persistent; GUS: Transition state; Drainflow: Moderately mobile; Potential for particle bound transport: Medium
Mainly stomach action but has some contact effects, Acetylcholinesterase (AchE) inhibitor.
CAS RN
12407-86-2
EC number
220-245-9
CIPAC number
130
US EPA chemical code
102401
PubChem CID
17592
CLP index number
No data found
Molecular mass
193.24
PIN (Preferred Identification Name)
reaction product comprising from 3.5 to 5 parts by mass of 3,4,5-trimethylphenyl methylcarbamate to 1 part by mass of 2,3,5-trimethylphenyl methylcarbamate
IUPAC name
reaction product comprising from 3.5 to 5 parts by mass of 3,4,5-trimethylphenyl methylcarbamate to 1 part by mass of 2,3,5-trimethylphenyl methylcarbamate
CAS name
2,3,5(or 3,4,5)-trimethylphenyl methylcarbamate
Other status information
Phytotoxic to some crop seeds including maize, wheat and rice
Relevant Environmental Water Quality Standards
-
Herbicide Resistance Class (HRAC MoA class)
Not applicable
Herbicide Resistance Class (WSSA MoA class)
Not applicable
Insecticide Resistance Class (IRAC MoA class)
1A
Fungicide Resistance Class (FRAC MOA class)
Not applicable
Examples of recorded resistance
-
Physical state
Off-white to brown granules
Formulations
Property
Value
Example manufacturers & suppliers of products using this active now or historically
Union Carbide
Example products using this active
Broot
Landrin
Formulation and application details
Usually supplied as a granular formulation
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
58
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Moderate
Solubility - In organic solvents at 20 °C (mg l⁻¹)
Octanol-water partition coefficient at pH 7, 20 °C
P
3.55 X 1002
Calculated
-
Log P
2.55
K3 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 3 = Unverified data of known source
Low
Fat solubility of residues
Solubility
-
-
-
Data type
-
-
-
Density (g ml⁻¹)
1.05
Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source
-
Dissociation constant pKa) at 25 °C
-
-
-
-
Vapour pressure at 20 °C (mPa)
6.8
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Moderately volatile. If applied directly to plants or soil, drift is a concern & mitigation is advisable
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
4.38 X 10-03
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Non-volatile
Volatilisation as max % of applied dose lost
From plant surface
-
-
-
From soil surface
-
-
-
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
-
-
-
Surface tension (mN m⁻¹)
-
-
-
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
DT₅₀ (typical)
20
DW4 DW = Don Wauchope personal database for Pka data: Wauchope, R. D. and Edwards, J. Dissociation constants for pesticide active ingredients: a database and comparison with predicted values. Dataset is no longer available. 4 = Verified data
Non-persistent
DT₅₀ (lab at 20 °C)
60
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
Moderately persistent
DT₅₀ (field)
50
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
Moderately persistent
DT₉₀ (lab at 20 °C)
-
-
-
DT₉₀ (field)
-
-
-
DT₅₀ modelling endpoint
-
-
-
Note
General literature states DT₅₀ 14 days in moist sand and 60 days in sterile soil and 42 days in dry, aerated soils
Dissipation rate RL₅₀ (days) on plant matrix
Value
-
-
-
Note
-
Dissipation rate RL₅₀ (days) on and in plant matrix
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT₅₀
-
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd (mL g⁻¹)
-
DW4 DW = Don Wauchope personal database for Pka data: Wauchope, R. D. and Edwards, J. Dissociation constants for pesticide active ingredients: a database and comparison with predicted values. Dataset is no longer available. 4 = Verified data
Moderately mobile
Koc (mL g⁻¹)
400
Notes and range
-
Freundlich
Kf (mL g⁻¹)
-
-
-
Kfoc (mL g⁻¹)
-
1/n
-
Notes and range
-
pH sensitivity
-
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
2.38
Calculated
Transition state
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
1.30 X 10-01
Calculated
-
Note
-
Potential for particle bound transport index
Medium
Calculated
-
Potential for loss via drain flow
Moderately mobile
Calculated
-
Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk
-
-
-
Bio-concentration factor
BCF (l kg⁻¹)
60
Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
-
-
-
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
> 25
Q1 Q = Miscellaneous data from online sources 1 = Estimated data with little or no verification
Estimated
Low
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
-
-
-
Mesocosm study data
NOEAEC mg l⁻¹
-
-
-
NOEAEC mg l⁻¹
-
-
-
Marine bivalves – Acute EC₅₀ development (mg l⁻¹)
-
-
-
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
Low (class I)
-
-
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
566
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
Rat
Moderate
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
-
-
-
Mammals - Inhalation LC₅₀ (mg l⁻¹)
-
-
-
Other Mammal toxicity endpoints
Acute percutanous LD₅₀ > 2000 mg kg⁻¹
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242
Environmental fate
Human health
