The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Human health High alert: Genotoxic; Endocrine disrupter; Reproduction/development effects
GENERAL INFORMATION
Description
A fungicide used to control a wide range of fungi including Tilletia and Helminthosporium spp. on fruit, vegetables and ornamentals
Example manufacturers & suppliers of products using this active now or historically
Bayer CropScience
Certis
Gustafson
Makhteshim-Agan
Example products using this active
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Formulation and application details
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ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
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Solubility - In organic solvents at 20 °C (mg l⁻¹)
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Melting point (°C)
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Boiling point (°C)
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Degradation point (°C)
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Flashpoint (°C)
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Octanol-water partition coefficient at pH 7, 20 °C
P
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Log P
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Fat solubility of residues
Solubility
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Data type
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Density (g ml⁻¹)
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Dissociation constant pKa) at 25 °C
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Vapour pressure at 20 °C (mPa)
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Henry's law constant at 25 °C (Pa m³ mol⁻¹)
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Volatilisation as max % of applied dose lost
From plant surface
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From soil surface
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Maximum UV-vis absorption L mol⁻¹ cm⁻¹
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Surface tension (mN m⁻¹)
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Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
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Soil degradation (days) (aerobic)
DT₅₀ (typical)
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DT₅₀ (lab at 20 °C)
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DT₅₀ (field)
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DT₉₀ (lab at 20 °C)
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DT₉₀ (field)
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DT₅₀ modelling endpoint
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Note
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Dissipation rate RL₅₀ (days) on plant matrix
Value
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Note
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Dissipation rate RL₅₀ (days) on and in plant matrix
Value
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Note
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Aqueous photolysis DT₅₀ (days) at pH 7
Value
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Note
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Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
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Note
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Water-sediment DT₅₀ (days)
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Water phase only DT₅₀ (days)
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Air degradation
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT₅₀
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Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd (mL g⁻¹)
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Koc (mL g⁻¹)
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Notes and range
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Freundlich
Kf (mL g⁻¹)
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Kfoc (mL g⁻¹)
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1/n
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Notes and range
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pH sensitivity
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Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
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SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
Cannot be calculated
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Note
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Potential for particle bound transport index
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Potential for loss via drain flow
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Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
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Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
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Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
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Mesocosm study data
NOEAEC mg l⁻¹
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NOEAEC mg l⁻¹
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Marine bivalves – Acute EC₅₀ development (mg l⁻¹)
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HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III)
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Mammals - Acute oral LD₅₀ (mg kg⁻¹)
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Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
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Mammals - Inhalation LC₅₀ (mg l⁻¹)
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Other Mammal toxicity endpoints
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ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
0.025
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
as imazalil
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ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
0.05
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
as imazalil
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Dermal penetration studies (%)
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Dangerous Substances Directive 76/464
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Exposure Routes
Public
No unacceptable risk to bystanders identified Consumers may be exposed via ingestion of contaminated foodstuffs
Occupational
No unacceptable risk for operators or other workers identified
MRLs
European
EU MRL pesticide database
Great Britain
GB MRL Register
Notes
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Drinking Water Standards
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Drinking Water MAC (μg l⁻¹)
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Mammalian dose elimination route and rate
Extensively metabolised and the main excretion routes are urine and faeces.
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
?Possibly, status not identified
A3 A = Chromosome aberration (EFSA database) 3 = Negative
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B1 B = DNA damage/repair (EFSA database) 1 = Positive
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C3 C = Gene mutation (EFSA database) 3 = Negative
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D0 D = Genome mutation (EFSA database) 0 = No data
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E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
✓Yes, known to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
XNo, known not to cause a problem
✓Yes, known to cause a problem
Eye irritant
Phototoxicant
✓Yes, known to cause a problem
No data found
General human health issues
Possible liver and kidney toxicant US EPA - probable human carcinogen; CLP data - suspected carcinogen
Handling issues
Property
Value and interpretation
General
Not explosive or oxidising IMDG Transport Hazard Class 6.1 Not expected to auto-ignite; Not highly flammable
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242
Human health
