Isoflucypram (Ref: BCS-CN88460)

Isoflucypram (Ref: BCS-CN88460)	Last updated: 02/03/2024
(Not known by any other names)

SUMMARY

Isoflucypram is a new cereals fungicide. It as a low aqueous solubility and is not considered highly volatile. Under certain conditions the substance may be persistent in both soil and water systems. No major human health issues have been identified but it may be a skin sensitiser or cause skin irritation. It is toxic to aquatic systems but is not considered harmful to insect pollinators.

Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate	Ecotoxicity	Human health
Environmental fate High alert: Potential for particle bound transport: High	Ecotoxicity High alert: Fish acute ecotoxicity: High	Human health Moderate alert: Reproduction/development effects

GENERAL INFORMATION

Description

A fungicide for the control of various steam-base, folia and ear fungal pathogens on cereals

Example pests controlled

Mycosphaerella graminicola, Puccinia recondita, Puccinia striiformis, Pyrenophora tritici-repentis

Example applications

Cereals including wheat, rye, triticale, barley, oats

Efficacy & activity

Availability status

Novel

Introduction & key dates

2019, first UK registration application

GB regulatory status

GB COPR regulatory status

Approved

Date COPR inclusion expires

03/10/2030

GB LERAP status

No data

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Pending

Dossier rapporteur/co-rapporteur

France

Date EC 1107/2009 inclusion expires

Not applicable

EU Candidate for substitution (CfS)

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece

ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg

LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia

Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries

ISIceland	NONorway

Additional information

Also used in

Chemical structure

Isomerism

Isoflucypram demonstrates stereo-isomerism

Chemical formula

C₁₉H₂₁ClF₃N₃O

Canonical SMILES

FC(F)c1nn(C)c(F)c1C(=O)N(Cc1cc(Cl)ccc1C(C)C)C1CC1

Isomeric SMILES

Not applicable

International Chemical Identifier key (InChIKey)

JEFUQUGZXLEHLD-UHFFFAOYSA-N

International Chemical Identifier (InChI)

InChI=1S/C19H21ClF3N3O/c1-10(2)14-7-4-12(20)8-11(14)9-26(13-5-6-13)19(27)15-16(17(21)22)24-25(3)18(15)23/h4,7-8,10,13,17H,5-6,9H2,1-3H3

2D structure diagram/image available?

Yes

General status

Pesticide type

Fungicide

Substance groups

Pyrazolecarboxamide fungicide; Carboximide fungicide

Minimum active substance purity

960 g kg⁻¹

Known relevant impurities

GB HSE dossier 2023: N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide <1.0 g kg⁻¹

Substance origin

Synthetic

Mode of action

Succinate Dehydrogenase Inhibitor (SDHI)

CAS RN

1255734-28-1

EC number

811-438-4

CIPAC number

None allocated

US EPA chemical code

PubChem CID

CLP index number

No data found

Molecular mass

399.84

PIN (Preferred Identification Name)

N-((5-chloro-2-(propan-2-yl)phenyl)methyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide

IUPAC name

N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide

CAS name

N-((5-chloro-2-(1-methylethyl)phenyl)methyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide

Other status information

Relevant Environmental Water Quality Standards

Herbicide Resistance Class (HRAC MoA class)

Not applicable

Herbicide Resistance Class (WSSA MoA class)

Not applicable

Insecticide Resistance Class (IRAC MoA class)

Not applicable

Fungicide Resistance Class (FRAC MOA class)

Examples of recorded resistance

Physical state

Whoite powder

Formulations

Property

Value

Example manufacturers & suppliers of products using this active now or historically

Bayer AG

Example products using this active

Isoflucypram EC50
Vimoy Iblon

Formulation and application details

Usually supplied as an emulsifiable concentrate and used as a foliar spray

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C (mg l⁻¹)

1.8

Low

Solubility - In organic solvents at 20 °C (mg l⁻¹)

1200

Heptane

260000

Toluene

97000

Methane

260000

Acetone

Melting point (°C)

108.8

Boiling point (°C)

Decomposes before boiling

Degradation point (°C)

215

Flashpoint (°C)

Octanol-water partition coefficient at pH 7, 20 °C

1.00 X 10⁰⁴

Calculated

Log P

4.0

at 25°C

High

Fat solubility of residues

Solubility

Data type

Density (g ml⁻¹)

1.22

Dissociation constant pKa) at 25 °C

No dissociation

Vapour pressure at 20 °C (mPa)

1.2 X 10^-04

Low volatility

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

2.7 X 10^-05

Non-volatile

Volatilisation as max % of applied dose lost

From plant surface

From soil surface

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

Neutral: 201nm=34777, 217nm=22116
Acid: 201nm=37165, 217nm=22539
Basic: 222bnm=21432

Surface tension (mN m⁻¹)

68.2

at 20 °C 83%

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Not readily biodegradable

Soil degradation (days) (aerobic)

DT₅₀ (typical)

431

Very persistent

DT₅₀ (lab at 20 °C)

431

Very persistent

DT₅₀ (field)

45.1

Moderately persistent

DT₉₀ (lab at 20 °C)

1727

Very persistent

DT₉₀ (field)

324

DT₅₀ modelling endpoint

333

Note

EU 2019 dossier lab studies DT₅₀ (normalised) range 206-665 days; DT₉₀ (normalised) range 685-2206 days, Soils=7; Field studies DT₅₀ (normalised) range 9.84-94.7 days; DT₉₀ (measured) range 69.6-3090 days, Soils=6; GB CRD 2023 dossier lab studies DT₅₀ (normalised) range 206-875 days, DT₉₀ (measured) range 685-2906 days, Soils=11

Dissipation rate RL₅₀ (days) on plant matrix

Value

Note

Dissipation rate RL₅₀ (days) on and in plant matrix

Value

Note

Aqueous photolysis DT₅₀ (days) at pH 7

Value

Stable

Note

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

Stable

Note

Stable at all relevant pH values

Water-sediment DT₅₀ (days)

388

Stable

Water phase only DT₅₀ (days)

1000

Stable

Air degradation

As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.

Decay in stored produce DT₅₀

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d (mL g⁻¹)

K_oc (mL g⁻¹)

Notes and range

Freundlich

K_f (mL g⁻¹)

33.96

Slightly mobile

K_foc (mL g⁻¹)

1636

¹/_n

0.918

Notes and range

EU 2019 dossier K_f range 11,.26-58.71 mL g⁻¹, K_foc range 1151-1569 mL g⁻¹, ¹/_n range 0.869-0.999, Soils=5; GB CRD 2023 dossier kf range 12.08-88.77 mL g⁻¹, kfoc range 1151-3594 mL g⁻¹, ¹/_n range 0.869-0.982, Soils=13

pH sensitivity

None

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

1.30

Calculated

Low leachability

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

3.00 X 10^-02

Calculated

Note

Potential for particle bound transport index

High

Calculated

Potential for loss via drain flow

Slightly mobile

Calculated

Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk

Bio-concentration factor

BCF (l kg⁻¹)

370

Threshold for concern

CT₅₀ (days)

Known soil metabolites

Metabolite

Major/Minor fraction

$Click here for further information on Major/Minor fraction$

Estimated maximum occurrence fraction

Notes

2-(4-chloro-2-((cyclopropyl((3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl)-carbonyl)amino)-methyl)phenyl}-propanoic acid (Ref: BCS-CY26497)

Major fraction

0.109

Bayer verified

2-{4-chloro-2-[(cyclopropyl{[3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl]carbonyl}amino)methyl]phenyl}-2-hydroxypropanoic acid (Ref: isoflucypram M10; BCS-CN88460-lactic acid; BCS-DH40620)

Minor fraction (aerobic)

2-{4-chloro-2-[(cyclopropyl{[3-(difluoromethyl)-5-fluoro-1H-pyrazol-4-yl]carbonyl}amino)methyl]phenyl}propanoic acid (Ref: isoflucypram M11; CS-CN88460-desmethylcarboxylic acid; BCS-CX99799)

Minor fraction (aerobic)

Known groundwater metabolites

Metabolite

EC SANCO/221/2000 relevancy

ADI (mg kg⁻¹ bodyweight day⁻¹)

WHO drinking water guidance value (μg L⁻¹ day⁻¹)

2-(4-chloro-2-((cyclopropyl((3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl)-carbonyl)amino)-methyl)phenyl}-propanoic acid (Ref: BCS-CY26497)

Relevant

0.04

240

Other known metabolites

Metabolite name and reference

Aliases

Formation medium / Rate

Estimated maximum occurrence fraction

N-[5-chloro-2-(2-hydroxypropan-2-yl)benzyl]-N-cyclopropyl-3-(difluoro-methyl)-5-fluoro-1-(gluco-pyranuronosyl)-1H-pyrazole-4-carboxamide

isoflucypram M38; BCS-CN88460-desmethyl-2-

Hen

2-{4-chloro-2-[(cyclopropyl{[3-(difluoromethyl)-5-fluoro-1H-pyrazol-4-yl]carbonyl}amino)methyl]phenyl}propyl 6-O-(carboxyacetyl)hexopyranoside

isoflucypram M41; S-CN88460-desmethylpropanol-Glyc-MA

Plant

isoflucypram M42; BCS-CN88460-desmethyl-1,2-propandiol-SA

Hen

gamma-glutamyl-S-{4-[(5-chloro-2-iso-propylbenzyl)(cyclopropyl)carbamoyl]-3-(difluoromethyl)-1-methyl-1H-pyrazol-5-yl}cysteinyl-beta-alanine

isoflucypram M44; S-CN88460-desfluorohomoGSH

Plant

N-(carboxyacetyl)-S-{4-[(5-chloro-2-isopropylbenzyl)(cyclo-propyl)carbamoyl]-3-(difluoromethyl)-1-methyl-1H-pyrazol-5-yl}cysteine

isoflucypram M45; CS-CN88460-desfluoro-CysMA

Plant

isoflucypram M46; BCS-CN88460-desfluoromercapto-lactic-OH

Plant

3-({4-[(5-chloro-2-isopropylbenzyl)(cyclopropyl)carbamoyl]-3-(difluoromethyl)-1-methyl-1H-pyrazol-5-yl}sulfanyl)-2-(hexo-pyranosyloxy)propanoic acid

isoflucypram M47; CS-CN88460-desfluoromercapto-lactic acid-Glyc

Plant

isoflucypram M48; CS-CN88460-desfluoromercapto-lactic acid-propylOH-Glyc

Plant

N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide

isoflucypram M49; S-CN88460-N-methylcyclopropyl-pyrazolecarboxamide

Plant

3-(difluoromethyl)-5-fluoro-1-methylpyrazole-4-carboxylic acid

isoflucypram M50; BCS-CN88460-N-methylpyrazole-carboxylic acid; BCS-AB72918; BCS-CR73065

Animal; Rat

isoflucypram M52; CS-CN88460-desfluoro-Nmethyl-cyclopropyl-pyrazolecarboxamide-OH-Cys

Plant

isoflucypram M54; S-CN88460-desfluoro-Nmethyl-cyclopropyl-pyrazolecarboxamide-OH-GSH

Rat; Plant

isoflucypram M55; CS-CN88460-desfluoro-Nmethyl-cyclopropyl-pyrazolecarboxamide-desamino-Cys

Plant

isoflucypram M56; BCS-CN88460-desfluoro-Nmethyl-cyclopropyl-pyrazolecarboxamide-mercapto-Gly

Plant

isoflucypram M57; CS-CN88460-desfluoro-Nmethyl-cyclopropyl-pyrazolecarboxamide-mercapto-GlycMA

Plant

N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1H-pyrazole-4-carboxamide

isoflucypram M58; CS-CN88460-cyclopropylpyrazole-carboxamide; BCS-CX99798

Rat; Plant

isoflucypram M62; S-CN88460-cyclopropylpyrazole-carboxamide-Glyc

Plant

3-[4-(cyclopropylcarbamoyl)-3-(difluoromethyl)-5-fluoro-1H-pyrazol-1-yl]alanine

isoflucypram M66; BCS-CN88460-cyclopropylpyrazole-carboxamide-Ala

Plant

3-[4-(cyclopropylcarbamoyl)-3-(difluoromethyl)-1H-pyrazol-1-yl]alanine

isoflucypram M67; CS-CN88460-desfluorocyclopropyl-pyrazolecarboxamide-Ala

Plant

isoflucypram M68; CS-CN88460-cyclopropylpyrazole-carboxamide-acetic acid

Plant

isoflucypram M69; CS-CN88460-cyclopropylpyrazole-carboxamide-OHlactic acid

Plant

5-chloro-2-isopropylbenzyl hexopyranosiduronic acid

isoflucypram M70; CS-CN88460-benzylalcoholGlucA

Rat

N-[5-chloro-2-(1-hydroxypropan-2-yl)benzyl]-N-cyclopropyl-5-fluoro-3-formyl-1H-pyrazole-4-carboxamide

isoflucypram M77; BCS-CN88460-desmethylpropanol-aldehyde; BCS-DH85957

Processing hydrolysis

N-[5-chloro-2-(2-hydroxypropan-2-yl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide

isoflucypram M02; BCS-CN88460-2-propanol; BCS-DC20298

Animal

N-[5-chloro-2-(1,2-dihydroxypropan-2-yl)benzyl]-N-cyclopropyl-3-(difluoro-methyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide

isoflucypram M03; BCS-CN88460-1,2-propandiol

Hen

yl N-(5-chloro-4-hydroxy-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide

isoflucypram M04; BCS-CN88460-hydroxyphenyl

Animal

N-[5-chloro-2-(1-hydroxypropan-2-yl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1H-pyrazole-4-carboxamide

isoflucypram M06; BCS-CN88460-desmethylpropanol

Animal; Plant

N-[5-chloro-2-(1,2-dihydroxypropan-2-yl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1H-pyrazole-4-carboxamide

isoflucypram M07; BCS-CN88460-desmethyl-1,2-propandiol

Animal

2-{4-chloro-2-[(cyclopropyl{[3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl]carbonyl}amino)methyl]phenyl}-2-hydroxypropanoic acid

isoflucypram M10; BCS-CN88460-lactic acid; BCS-DH40620

Rat

2-{4-chloro-2-[(cyclopropyl{[3-(difluoromethyl)-5-fluoro-1H-pyrazol-4-yl]carbonyl}amino)methyl]phenyl}propanoic acid

isoflucypram M11; CS-CN88460-desmethylcarboxylic acid; BCS-CX99799

Rat

2-(4-chloro-2-((cyclopropyl((3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl)-carbonyl)amino)-methyl)phenyl}-propanoic acid

isoflucypram M12; BCS-CN88460-carboxylic acid

Animal

N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1H-pyrazole-4-carboxamide

isoflucypram M13; BCS-CN88460-desmethyl

Animal

N-{5-chloro-2-[1- N-{5-chloro-2-[1-yl]benzyl}-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide

isoflucypram M18; BCS-CN88460-propanol-Glyc

Plant

2-{4-chloro-2-[(cyclopropyl{[3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl]-carbonyl}amino)methyl]phenyl}propyl glucopyranosiduronic acid

isoflucypram M19; BCS-CN88460-propanol-GlucA

Animal

2-chloro-4-[(cyclopropyl{[3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl]-carbonyl}amino)-methyl]-pyrazol-4-yl]-carbonyl}amino)-methyl]-(carboxyacetyl)-beta-D-glucopyranoside

isoflucypram M23; CS-CN88460-hydroxyphenylGluc-MA

Plant

2-chloro-4-[(cyclopropyl{[3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl]-carbonyl}amino)-methyl]-5-isopropyl-phenyl 6-O-(carboxyacetyl)-hexopyranoside

isoflucypram M24; BCS-CN88460-hydroxyphenylGlyc-MA

Plant

2-{4-chloro-2-[(cycloprop yl{[3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl]carbonyl}amino)methyl]phenyl}prop-2-en-1-yl beta-D-glucopyranosiduronic acid

isoflucypram M25; BCS-CN88460-propenol-GlucA

Animal

2-{4-chloro-2-[(cyclopropyl{[3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl]carbonyl}amino)methyl]phenyl}propyl hydrogen sulfate

isoflucypram M26; BCS-CN88460-propanol-SA

Hen

isoflucypram M27; CS-CN88460-1,2-propandiolSA

Hen

2-{4-chloro-2-[(cyclopropyl{[3-(difluoromethyl)-5-fluoro-1H-pyrazol-4-yl]carbonyl}amino)methyl]phenyl}propyl glucopyranosiduronic acid

isoflucypram M31; BCS-CN88460-desmethylpropanol-GlucA

Rat

N-(5-chloro-2-isopropylbenzyl)-N-N-(5-chloro-2-isopropylbenzyl)-N-fluoro-1-(beta-D-glucopyranuronosyl)-1H-pyrazole-4-carboxamide

isoflucypram M35; CS-CN88460-desmethylGlucA

Rat

N-[5-chloro-2-(1,2-dihydroxypropan-2-yl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-(gluco-pyranuronosyl)-1H-pyrazole-4-carboxamide

isoflucypram M36; BCS-CN88460-desmethyl-1,2-propandiol-N-GlucA

Hen

N-[5-chloro-2-(1-hydroxypropan-2-yl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-(gluco-pyranuronosyl)-1H-pyrazole-4-pyranuronosyl)-1H-pyrazole-4-

isoflucypram M37; BCS-CN88460-desmethylpropanol-N-Gluc

Hen

2-{4-chloro-2-[(cyclopropyl{[3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl]carbonyl}amino)methyl]phenyl}propan-2-yl beta-D-glucopyranosiduronic acid

isoflucypram M20; CS-CN88460-2-propanolGlucA

Animal

2-{4-chloro-2-[(cyclopropyl{[3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl]-carbonyl}amino)methyl]phenyl}propyl-6-O-(carboxyacetyl)hexopyranoside

isoflucypram M21; CS-CN88460-propanol-GlycMA

Plant

2-{4-chloro-2-[(cyclopropyl{[3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl]-carbonyl}amino)-methyl]phenyl}propan-2-yl 6-O-(carboxy-acetyl)hexopyranoside

isoflucypram M22; BCS-CN88460-2-propanolGlyc-MA

Plant

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 2000

Rat

Low

Mammals - Short term dietary NOEL

(mg kg⁻¹)

(ppm diet)

Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)

Birds - Acute LD₅₀ (mg kg⁻¹)

3776

Colinus virginianus

Low

Birds - Short term dietary (LC₅₀/LD₅₀)

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)

14.5

Eisenia foetida corr

Moderate

Soil micro-organisms

Nitrogen transformation: No significant adverse effect

Dose: 0.53 mg kg⁻¹ soil 28 Day

Collembola

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

49.5

Folsomia candida corr

Non-target plants

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 100.0

Apis mellifera

Low

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 106.3

Apis mellifera

Low

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Chronic as 10-day LDD₅₀ µg bee⁻¹ day⁻¹

89.7

Apis mellifera

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 100

Bombus terrestris

Low

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 200.2

Bombus terrestris

Low

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other bee species (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other bee species (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Beneficial insects (Ladybirds) as Mortality LR₅₀ g ha⁻¹

> 75

Coccinella septempunctata

Beneficial insects (Lacewings) as Mortality LR₅₀ g ha⁻¹ Protonymphs

> 75

Chrysoperla carnea

Beneficial insects (Parasitic wasps) as Mortality LR₅₀ g ha⁻¹

14.13

Aphidius rhopalosiphi

Beneficial insects (Predatory mites) as Mortality LR₅₀ g ha⁻¹

30.6

Typhlodromus pyri

Beneficial insects (Ground beetles)

Aquatic ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

0.098

Oncorhynchus mykiss

High

Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

0.201

Daphnia magna

Moderate

Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

0.020

Americamysis bahia 28 day NOEC

High

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

100

Chironomus dilutus

Low

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)

> 2.48

Lemna gibba NOEC

Moderate

Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)

> 2.02

Pseudokirchneriella subcapitata

Moderate

Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)

Mesocosm study data

NOEAEC mg l⁻¹

Marine bivalves – Acute EC₅₀ development (mg l⁻¹)

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 2000

Rat

Low

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

2000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

2.5

Rat 4 hr (aerosol nose only)

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

0.04

Dog SF=100

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

0.7

rabbit SF=100

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

None allocated

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

0.04

Dog SF=100

Dermal penetration studies (%)

2.8-6.3

Dangerous Substances Directive 76/464

Exposure Routes

Public

Low risk for prescribed uses

Occupational

Low risk for prescribed uses

MRLs

European

EU MRL pesticide database

Great Britain

GB MRL Register

Notes

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

Mammalian dose elimination route and rate

Rapid and extensive elimination as metabolites mainly via bile (78-85%)

Health issues

Specific human health issues

Carcinogen

Genotoxic

Endocrine disruptor

No data found

; ; ; ;

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

Respiratory tract irritant

Skin irritant

Skin sensitiser

Eye irritant

Phototoxicant

General human health issues

Possible thyroid, liver and kidney toxicant

Handling issues

Property

Value and interpretation

General

Not explosive or oxidising
Not expected to auto-ignite; Not highly flammable

CLP classification 2013

Health: H317, H332, H361f
Environment: H400, H410

WHO Classification

Not listed (Not listed)

UN Number

Waste disposal & packaging

Shelf-life, storage, stability and reactivity

TRANSLATIONS

Language

Name

English

isoflucypram

French

German

Danish

Italian

Spanish

Greek

Polish

Swedish

Hungarian

Dutch

Norwegian

Record last updated:	02/03/2024
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242